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Some studies have shown sulindac to be relatively less irritating to the stomach than other NSAIDs except for drugs of the COX-2 Treprostinil synthesis class[ citation needed ]. A Reformatsky reaction with zinc amalgam and bromoacetic ester leads Treprostinil synthesis carbinol 5which is then dehydrated with tosic acid to indene 6.

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Regulates the peroxisomal beta-oxidation pathway of fatty acids. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low.

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More specifically, the agent is converted by liver enzymes to a sulfide that is excreted in the bile and then reabsorbed from the intestine. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation.

Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene.

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Sulindac is a prodrugderived from sulfinylindenethat is converted in the body to the active NSAID. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid.

Gene Ontology GO annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity.

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It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Once activated by a ligand, the receptor binds to promoter elements of target genes.

Sulindac seems to have a property, independent of COX-inhibition, of reducing the growth of polyps and precancerous lesions in the colon, especially in association with familial adenomatous polyposisand may have other anti-cancer properties.

Its usual dosage is milligrams twice per day, with food. Decreases expression of NPC1L1 once activated by a ligand.

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It should not be used by persons with a history of major allergic reactions urticaria or anaphylaxis to aspirin or other NSAIDs, and should be used with caution by persons having pre-existing peptic ulcer disease.

The case had been appealed to the United States Supreme Court, where the main issue was whether federal law preempts Ms. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.

The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling.

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This is thought to help maintain constant blood levels with reduced gastrointestinal side effects. In common with other NSAIDs, sulindac is currently being investigated for its role in the treatment of Alzheimer's disease.

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Among its related pathways are Ectoderm Differentiation and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.